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来源：百度知道 编辑：UC知道 时间：2024/07/08 17:56:52
题目1：Aryl Thiol Substrate 3-Carboxy-4-Nitrobenzenethiol Strongly Stimulating Thiol Peroxidase Activity of Glutathione Peroxidase Mimic 2, 2'-Ditellurobis(2-Deoxy-β-Cyclodextrin)
Abstract：
Artificial glutathione peroxidase (GPx) model 2, 2'-ditellurobis(2-deoxy-β-cyclodextrin) (2-TeCD) which has the desirable properties exhibited high substrate specificity and remarkably catalytic efficiency when 3-carboxy-4-nitrobenzenethiol (ArSH) was used as a preferential thiol substrate. The complexation of ArSH with β-cyclodextrin was investigated through UV spectral titrations, fluorescence spectroscopy, 1H NMR and molecular simulation, and these results indicated that ArSH fits well to the size of the cavity of β-cyclodextrin. Furthermore, 2-TeCD was found to catalyze the reduction of cumene peroxide (CuOOH) by ArSH 200 000-fold more efficiently than diphenyl diselenide (PhSeSePh). Its steady-state kinetics was studied and the second rate constant kmax/KArSH was found to be 1.05
Abstract：
Artificial glutathione peroxidase (GPx) model 2, 2'-ditellurobis(2-deoxy-β-cyclodextrin) (2-TeCD) which has the desirable properties exhibited high substrate specificity and remarkably catalytic efficiency when 3-carboxy-4-nitrobenzenethiol (ArSH) was used as a preferential thiol substrate. The complexation of ArSH with β-cyclodextrin was investigated through UV spectral titrations, fluorescence spectroscopy, 1H NMR and molecular simulation, and these results indicated that ArSH fits well to the size of the cavity of β-cyclodextrin. Furthermore, 2-TeCD was found to catalyze the reduction of cumene peroxide (CuOOH) by ArSH 200 000-fold more efficiently than diphenyl diselenide (PhSeSePh). Its steady-state kinetics was studied and the second rate constant kmax/KArSH was found to be 1.05
烷基硫醇3-Carboxy-4-Nitrobenzenethiol强烈刺激硫醇基体的模拟酶活性胱甘肽过氧化酶,2(2-Deoxy-β-Cyclodextrin -Ditellurobis)。
文摘:
谷胱甘肽过氧化酶(GPx人为二)模型2)(2-TeCD -ditellurobis(2-deoxy-β-cyclodextrin具有理想特性)的高底物特异性展出的、显著的催化效率(ArSH 3-carboxy-4-nitrobenzenethiol时)被用作一优惠硫醇基质。这个complexation ArSH的研究与β-cyclodextrin紫外光谱滴定通过核磁共振氢谱、荧光光谱,和分子模拟,这些结果表明ArSH很合身的尺寸的β-cyclodextrin。另外,2-TeCD被发现催化还原cumene过氧化氢(CuOOH ArSH)更有效的200 000-fold苯diselenide(PhSeSePh比)。它的稳态动力学研究和第二个速率常数kmax / KArSH被发现1.05 M-1 min-1×107类似,自然GPx。此外,动力学数据显示,催化效率的影响取决于2-TeCD双方认可的竞争力为2-TeCD底。催化机理和2-TeCD催化机理,在一个乒乓球和自然GPx类比,而且可能会发挥其硫醇过氧化酶活动,通过tellurol tellurenic酸、tellurosulfide。